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˼飨ģ

ʿйѧ Ժҽҩ 뽡оԺ鳤ҩﻯѧ ӦûоΧơҩб귢 ȷ֤ҩȵ  һչǰٰش󼲲  ۺ ѧҩơҩﻯѧͽ ѧѧƽϲԣ չҩб귢ȷ֤ҩûоԼ ҩ↑Ϊҩ춨˰бѧʻȡϵͳ Ĵ ³ɹ еԹصзȻѧпԺԻҩоȵר㶫ʡȻѧ оŶӵĿ  Ⱥ󷢱Nature Medicine, Cell Research, Nat Struct Mol Biol, J Med ChemEur J Med Chemѧϡ

ݼģ

ǰٰPCaĶ֮һռȫ ʵڶλٴǰҪۼذƷADTǰٰȻлնᷢչΪ ԵȥƵֿǰ CRPCȻFDA׼ĵڶۼҩ³EnzalutamideͰAbirateroneԻ⼲չһ ĹЧߺܿٴҩˣ ٴҪ ҩǰٰ²ԡͨƱŴ BETṹBromodomainӰۼ   ͨ·ǽǰ ҩ ǰ ٰһ DZ²ԡںҩƣϲһ͵ģı[d]fǼܽṹڸùǼܣͨ ӶӺ͸ ᄃṹϢָƼŻջ˻ ͱ ЧBET ṹƼԻ6iY060367mY06137BRD41ĽKdֱֵΪ8281 nM32 ṹ򵰰׵ѡУ6i7mֳԽѡԡ

 


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